Conflict and instability have been constant features of the Middle East for decades. Over the most recent decade, four civil wars and fraught relationships between the major regional powers have been pushing the region toward a potentially perilous political and economic future. We know that the COVID-19 crisis is disrupting the status quo on nearly everything, including regional conflict. What we do not know is how that disruption today might worsen — or improve — the trendlines of those conflicts as we head toward 2025. In this MEI Strategic Foresight Initiative paper we employ a scenario-based methodology to explore this question.